SPE

Special silica phase for SPE enrichment of drugs from urine or plasma

Base material silica, pore size 60Å, particle size 45µm, specific surface 500m²/g, pH stability 2 to 8, special bifunctional modification - C₈/SA (strong cation exchanger - benzenesulphonic acid).

Recommended application: enrichment of acidic, neutral and basic drugs from urine or plasma.

Polar modified polystyrene-divinylbenzene copolymer with a weak anion exchanger

Specific surface 650 to 700 m²/g, particle size 80µm, pore size 50 Å, pH stability 1 to 14. Due to bifunctional modification much more hydrophilic than conventional polystyrene-divinylbenzene polymers and thus easily wettable with water.

Recommended applications: polar herbicides / pesticides from water (acidic, neutral, basic), polar phenols from water, polyaromatic compounds, polychlorinated biphenyls, drug analysis from urine, blood, serum, plasma pharmaceuticals / active ingredients from tablets, creams.

Due to the bifunctional modification CHROMABOND^® Easy is considerably more hydrophilic than conventional polystyrene-divinylbenzene polymers and thus easily wettable with water. The Easy effect: Aqueous samples can be loaded directly without preconditioning! This means that little or even no conditioning is needed, in contrast to standard SPE materials, where recovery rates normally decrease, in the worst case down to zero! Depending on the separation task conditioning may be required and is recommended for method development. A positive side effect of the excellent wettability: there is no decrease of recovery rates, if the cartridge runs dry, therefore automation is easier or, in some cases compared to silica materials, only feasible with CHROMABOND^® Easy, because a permanent vacuum can be used without supervision.

Further advantages of using a polymeric material:

• high surface, this means very high binding capacity (2 - 5 times higher than silica-based adsorbents)
• less adsorbent is needed in the cartridge (without losing sensitivity or recovery)
• faster analysis, because the height of the adsorbent bed can be reduced
• acidic or basic solvents (e. g. TFA) do not destroy the phase, or lead to unintended side products

Because of the polar modification the material is suitable for a broad range of compounds (acidic, neutral, basic, polar and nonpolar substances). Highly reproducible recovery rates can be obtained, even if the cartridge runs dry (especially advantageous when using 96-well plates, where stopcocks are not available!)

Magnesium silicate for SPE

Matrix magnesium silicate (MgO to SiOH 15:85), high purity, particle size 150 to 250µm.

Recommended application: organic tin compounds, aliphatic carboxylic acids, PCB, PAH.

Spherical, hydrophobic polystyrene-divinylbenzene resin for SPE
Hydrophobic polystyrene-divinylbenzene copolymer pH stability 1 to14. High-purity material with highest reproducibility and lowest blank values due to a novel manufacturing process, spherical particles 85mm; pore size 55 to 60Å. Very high surface 1000m²/g; capacity 390mg/g (caffeine in water). Excellent recovery rates especially for the enrichment of pharmaceuticals/active ingredients due to the spherical structure of the particles, very homogeneous surface, and optimised pore structure.

Recommended applications: pharmaceuticals/active ingredients from tablets, creams and water/waste water, drugs and pharmaceuticals from urine, blood, serum and plasma trace analysis of pesticides.

The innovative cation exchanger offers:

mixed-mode SPE phase with distinct cation exchange and RP properties excellent enrichment of basic analytes
modern support polymer with optimised pore structure and large specific surface
good reproducibility, reliable and cost-efficient analyses
more aggressive washing procedures for matrix removal possible
cleaner samples and protection of analytical HPLC and GC instrumentation
quantificationof analytes from heavily contaminated samples
lower limits of detection also for critical matrices

... the perfect fit for basic analytes in comination with CHROMABOND^® HR-X
Benzenesulfonic acid modified polymeric cation exchanger for SPE

Base material spherical PS/DVB copolymer, pore size 65-75Å, particle sizes 45µm or 85µm (standard), very large specific surface 800m²/g, pore volume 1.4cm³/g, pH stability 1-14. Benzenesulfonic acid modification, exchange capacity 1.0meq/g, pKa < 1 RP capacity 300mg/g (caffeine in water). High-purity material, highest reproducibility and lowest blank values due to an optimized production process, outstanding recovery rates especially for the enrichment of basic analytes for standard protocol.

Recommended application: basic active ingredients from strongly matrix-contaminated samples like, e.g., urine, plasma, serum, fungicides from food, basic analytes like, e.g., amines, bases with pKa 2-10.

Special phase for SPE analysis of PCB from sludge

Special combination phase:
N: sodium sulphate for removal of trace water.
A: SiOH/AgNO₃ phase for removal of sulphur, sulphur-containing and polar compounds.

Recommended application: extraction of PCB from sludge.

Diol modified silica phase for SPE

Base material silica, pore size 60Å, particle size 45µm, specific surface 500m²/g, pH stability 2 to 8, diol phase, carbon content 5.5%, polar properties similar to SiOH.

Recommended application: antibiotics, prostaglandins.

Polyamide 6 for SPE

Matrix polyamide 6, unmodified, high purity, particle size 40 to 80µm.

Recommended application: flavonoids, PAH.

The innovative cation exchanger offers:

mixed-mode SPE phase with distinct cation exchange and RP properties excellent enrichment of basic analytes
modern support polymer with optimised pore structure and large specific surface
good reproducibility, reliable and cost-efficient analyses
more aggressive washing procedures for matrix removal possible
cleaner samples and protection of analytical HPLC and GC instrumentation
quantificationof analytes from heavily contaminated samples
lower limits of detection also for critical matrices

... the perfect fit for basic analytes in comination with CHROMABOND^® HR-X
SPE phases for polymer-based RP and ion chromatography

Base material: high-purity polystyrene-divinylbenzene copolymers (PS/DVB)
pore size 100 Å, paricle size 100µm. Verly low degree of swelling, thus very well suited for chromatography. Different modifications for different applications from elimination of nonpolar compounds up to removal of specific polar comonents.

Recommended application:
Removal of interfering compounds

• improves chromatographic separtions, if the interfering components overlap with the analyte in the chromatogram
• improves lifetime of the chromatographic column, since interfering components can irreversibly block the column packing

removal or concentration of anions from water increasing the pH value in acidic samples removal or concentration of cations from water	PS-OH- strong PS/DVB anion exanger, OH- form capacity 0,6 meq/g
decreasing the pH value in basic samples	PS-H+ strong PS/DVB cation exchanger, H+ form, capacity 2,9 meg/g

Propylsulphonic acid modified silica cation exchanger for SPE

Base material silica, pore size 60Å, particle size 45µm, specific surface 500m²/g, pH stability 2 to 8, propylsulphonic acid modified silica, very strong cation exchanger (capacity ~ 0.7meq/g), contrary to the SA phase no P-P interactions.

Recommended applications: weak cations.