Filter
15-keto Latanoprost ANWENDUNG:
Bioactive lipid studies
WISSENSCHAFTSGEBIET: Bioactive Lipids
SONSTIGE INFOS: Latanoprost is an F-
series prostaglandin (PG) analog
which has been approved for use as an
ocular hypotensive drug. Oxidation of
the C
-15 hydroxyl group without
isopropyl ester hydrolysis produces
15-keto latanoprost. 15-keto
Latanoprost is a potential metabolite
of latanoprost when administered to
intact animals. 15-keto Latanoprost
is also one of the common minor
impurities found in commercial
preparations of the bulk drug
compound. Although much less potent
that the parent compound latanoprost,
15-keto latanoprost still retains the
ability to produce a small but
measurable decrease (1 mm Hg) in the
intraocular pressure of normal
cynomolgus monkeys when administered
at a dose of 1 µg/eye. 15-keto
Latanoprost is also a miotic in the
normal cat eye, causing an 8 mm
reduction in pupillary diameter at 5
µg/eye. Again, this is not as potent
as many other F-type PGs, for
example, PGF2alpha will produce this
degree of miosis at a dose of less
than 1 µg/eye. Products of beta-
oxidation account for most of the
metabolites of latanoprost recovered
in plasma and urine. However, 15-keto
latanoprost is a minor metabolite,
and one which could be enhanced in
situations where beta-oxidation is
reduced.
Zeige mehr
Biomol
Tabelle schließen
| Bestell Nr. | Packungsgröße | Preis pro Packung | |||
|---|---|---|---|---|---|
|
CAY16816-1 Dieser Artikel aus unserem Sortiment entspricht Ihrer Suche. |
1 mg | Zum Login / Registrierung |
|
||
|
CAY16816-5 Dieser Artikel aus unserem Sortiment entspricht Ihrer Suche. |
5 mg | Zum Login / Registrierung |
|
||
|
CAY16816-10 Dieser Artikel aus unserem Sortiment entspricht Ihrer Suche. |
10 mg | Zum Login / Registrierung |
|
||
|
CAY16816-100 Dieser Artikel aus unserem Sortiment entspricht Ihrer Suche. |
100 mg | Zum Login / Registrierung |
Artikel zur Streichung vorgesehen
|